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gentamicine

J - Antiinfectives For Systemic Use -> J01 - Antibacterials For Systemic Use -> J01G - Aminoglycoside Antibacterials -> J01GB - Other Aminoglycosides -> J01GB03 - Gentamicin
Administration category: Free Medicine group: antibacterial

Standard dosages

≥ 18 years
WeightROALoadDosage
ROA:
iv
Load:
-
Dosage:
5mg/kg 1 dd

Kidney function

≥ 18 years
ROAGFRDosageIntervalComments
ROA: iv
GFR:
50 - 80
Interval:
36 Hours
GFR:
30 - 50
Interval:
48 Hours
GFR:
10 - 30
Dosage:
doseren op geleide van de serumconcentratie
Renal elimination: 90%
Dosage: dependent on kidney function

Renal function-replacement therapy

CAPD: Normale aanvangsdosis, vervolgens interval verlengen op geleide van de spiegel.

Hemo dialysis: Normale aanvangsdosis, vervolgens interval verlengen op geleide van de spiegel. Op dialysedagen: bij toedienen voor dialyse normale dosis; bij toedienen na de dialyse de helft tot een derde van de dosis.

CAV / VVHD: Normale aanvangsdosis, vervolgens interval verlengen op geleide van de spiegel.

Interactions

Interaction with (ATC): Interaction with: Expected effect:
Interaction with (ATC):
L04AD01 - Ciclosporin
Interaction with:
Expected effect:
verhoogde kans op nefrotoxiciteit
Interaction with (ATC):
L01XA01 - Cisplatin
Interaction with:
in de afgelopen 6 maanden
Expected effect:
verhoogde kans op nefrotoxiciteit
Interaction with (ATC):
J01XA01 - Vancomycin
Interaction with:
Expected effect:
verhoogde kans op nefrotoxiciteit
Interaction with (ATC):
C03CA01 - Furosemide
Interaction with:
Expected effect:
verhoogde kans op nefro- en ototoxiciteit
Interaction with (ATC):
J02AA01 - Amphotericin B
Interaction with:
Expected effect:
verhoogde kans op nefro- en ototoxiciteit
Interaction with (ATC):
Interaction with:
neuromusculaire spierrelaxantia
Expected effect:
toename neuromusculaire blokkade

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.
Metadata

Swab vid: M-1481.2
Updated: 06/16/2019 - 20:05
Status: Published

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